Publications

M. Kanarik, K. Liiver, M. Školnaja, I. Teino, T. Org, K. Laugus, R. Shimmo, M. Karelson, M. Saarma, J. Harro, RNA m6A methyltransferase activator affects anxiety-related behaviours, monoamines and striatal gene expression in the rat, (2024). https://doi.org/10.1017/neu.2024.36

L.-Y. Yu, S. Selberg, I. Teino, J. Nam, L. Ivanova, B. Renzi, N. Seli, E. Kankuri, M.H. Voutilainen, M. Karelson, M. Saarma, Small molecule activation of m6A mRNA methylation as a novel approach for neuroprotection, (2023). https://doi.org/10.1101/2023.07.05.547860.

S. Selberg, L. Ivanova, M. Kotli, K. Herodes, D. Blokhina, E. Kankuri, N. Seli, I. Ilves, I. Teino, M. Saarma, M. Karelson, Novel RNA m 6 A methyltransferase METTL16 inhibitors, (2023). https://doi.org/10.1101/2023.03.27.534333.

S. Selberg, N. Seli, E. Kankuri, M. Karelson, Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors, ACS Omega 6 (2021) 13310–13320. https://doi.org/10.1021/acsomega.1c01289.

S. Selberg, L.-Y. Yu, O. Bondarenko, E. Kankuri, N. Seli, V. Kovaleva, K. Herodes, M. Saarma, M. Karelson, Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons, IJMS 22 (2021) 4537. https://doi.org/10.3390/ijms22094537.

S. Selberg, E. Žusinaite, K. Herodes, N. Seli, E. Kankuri, A. Merits, M. Karelson, HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators, ACS Omega 6 (2021) 15957–15963. https://doi.org/10.1021/acsomega.1c01626.

S. Selberg, D. Blokhina, M. Aatonen, P. Koivisto, A. Siltanen, E. Mervaala, E. Kankuri, M. Karelson, Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site, Cell Reports 26 (2019) 3762-3771.e5. https://doi.org/10.1016/j.celrep.2019.02.100.