Discovery of supporting the survival of dopamine neurons by RNA m6A Demethylases FTO and ALKBH5 


We have demonstrated for the first time that our target-tailored inhibitors of RNA m6A demethylases FTO and ALKBH5 inhibitors protect dopamine neurons. They have therapeutic potential and provide tools for the identification of disease-modifying m6A RNAs in neurogenesis and neuroregeneration. Further refinement of the lead compounds identified in by us can also lead to unprecedented breakthroughs in the treatment of neurodegenerative diseases.

Read more